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Researchers have found murine leukemia viruses (MLV) in blood samples collected from patients diagnosed with chronic fatigue syndrome (CFS) and some healthy blood donors, according to a study published online today by the scientific journal Proceedings of the National Academy of Sciences (PNAS).
Food and Drug Administration (Ematologia) - Mar, 31 Agosto 2010
http://www.fda.gov
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Neurofibromatosis type 1 (NF1) is the most common genetic disorder with a predisposition to malignancy and affects 1 in 3500 persons worldwide.
Blood (Ematologia) - Gio, 22 Luglio 2010
http://www.bloodjournal.org/
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The optimal primary endpoint for acute graft-versus-host disease (GVHD) therapeutic trials has not been established.
Blood (Ematologia) - Lun, 5 Luglio 2010
http://www.bloodjournal.org/
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Young people under the age of 25 contribute an estimated 38% of all voluntary blood donations. World Blood Donor Day held on 14 June has the slogan, "New blood for the world," to raise awareness of the important role young people play in maintaining supplies of safe blood.
World Health Organization (Ematologia) - Mer, 16 Giugno 2010
http://www.who.int
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During erythrocyte invasion, Plasmodium falciparum merozoites use multiple receptor-ligand interactions in a series of coordinated events, but current knowledge of these interactions is limited. Using real-time imaging of invasion, we established that heparin-like molecules block early, and essential, events in erythrocyte invasion by merozoites. All P falciparum isolates tested, and parasites using different invasion pathways were inhibited to comparable levels. Furthermore, it was not possible to select for heparin-resistant parasites. Heparin-like molecules occur naturally on the surface of human erythrocytes, where they may act as receptors for binding of merozoite surface proteins. Consistent with this, we demonstrated that MSP1-42, a processed form of merozoite surface protein 1 (MSP1) involved in invasion, bound heparin in a specific manner; furthermore, binding was observed with the secondary processing fragment MSP1-33, but not MSP1-19. We defined key structural requirements of heparin-like molecules for invasion inhibition and interactions with MSP1-42. Optimal activity required a degree of sulfation more than or equal to 2, disulfation of the N-acetylglucosamine or hexuronic acid residue, and a minimum chain length of 6 monosaccharides. These findings have significant implications for understanding P falciparum invasion of erythrocytes and the development of novel therapeutics and vaccines.
Blood (Ematologia) - Mar, 8 Giugno 2010
http://www.bloodjournal.org/
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Recent studies have reported that regions of homozygosity (ROH) in the genome are detectable in outbred populations and can be associated with an increased risk of malignancy. To examine whether homozygosity is associated with an increased risk of developing childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL), we analyzed 824 ALL cases and 2398 controls genotyped for 292 200 tagging SNPs. Across the genome, cumulative distribution of ROH was not significantly different between cases and controls. Four common ROH at 10p11.2-10q11.21, 1p31.1, 19p13.2-3, and 20q11.1-23 were, however, associated with ALL risk at P less than .01 (including 1 ROH to which the erythropoietin receptor [EPOR] gene maps, P = .005) but were nonsignificant after adjusting for multiple testing. Our findings make it unlikely that levels of measured homozygosity, caused by autozygosity, uniparental isodisomy, or hemizygosity, play a major role in defining BCP-ALL risk in predominantly outbred populations.
Blood (Ematologia) - Mar, 8 Giugno 2010
http://www.bloodjournal.org/
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A DNA-vaccine that restricts the supply of blood to tumours has been developed by scientists at the Karolinska Institutet. The vaccine slows the growth of breast cancer tumours in mice.
Karolinska Institutet (Ematologia) - Lun, 31 Maggio 2010
http://ki.se/ki/jsp/polopoly.jsp?d=130&l=en
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White blood cell infiltration across an activated brain endothelium contributes to neurologic disease, including cerebral ischemia and multiple sclerosis.
Blood (Ematologia) - Lun, 3 Maggio 2010
http://www.bloodjournal.org/
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Myelodysplastic syndrome is about 5 times more common than previously believed, and is associated with substantial and serious comorbid illnesses.
Medscape (Ematologia) - Lun, 3 Maggio 2010
http://www.medscape.com
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Fanconi anemia (FA) is a genetically heterogeneous, autosomal recessive disorder characterized by pediatric bone marrow failure and congenital anomalies.
Blood (Ematologia) - Lun, 3 Maggio 2010
http://www.bloodjournal.org/