Dermatologia

Methotrexate and azathioprine for the treatment of atopic eczema

Patients with severe atopic eczema may require prolonged treatment with large amounts of highly potent topical corticosteroids and/or systemic treatment. In an upcoming issue of The Journal of Allergy and Clinical Immunology, Schram et al show results of the first head-to-head comparison of azathioprine versus methotrexate for the treatment of patients with severe atopic eczema. The authors conclude that both methotrexate and azathioprine are effective and safe short-term treatment options for adult patients with severe atopic eczema. The results from this study justify treatment with these drugs when routine treatment is insufficient. Long-term follow-up of these patients is necessary to gather additional information.
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American Academy of Allergy, Asthma and Immunology