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Common variants and haplotypes within the RORA gene appear to act synergistically with the ARMS2 A69S polymorphism to increase risk of neovascular AMD. These data add further evidence of a high level of complexity linking genetic and modifiable risk factors to AMD development and should help efforts at risk prediction.
Archives of Ophthalmology - Mar, 9 Novembre 2010
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Retinal ganglion cells are usually not able to regenerate their axons after optic nerve injury or degenerative disorders, resulting in lifelong visual loss. This situation can be partially reversed by activating the intrinsic growth state of retinal ganglion cells, maintaining their viability, and counteracting inhibitory signals in the extracellular environment. Advances during the past few years continue to extend the amount of regeneration that can be achieved in animal models. These findings give hope that clinically meaningful regeneration may become a reality within a few years if regenerating axons can be guided to their appropriate destinations.
Archives of Ophthalmology - Mar, 31 Agosto 2010
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The genomic era has produced an extensive catalog of human genes and genetic variation that is expected to become even more detailed with the addition of the rich data emerging from the 1000 Genomes Project (http://www.1000genomes.org).
Archives of Ophthalmology - Mer, 14 Luglio 2010
http://archopht.ama-assn.org/
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The management of monocular infantile cataract is one of the most time-consuming medical tasks that infants' parents and ophthalmologists undertake. Surgical care is only the first step. Associated management issues create a life-long relationship for the child with ophthalmology. Problems that these families encounter include a frequently changing refractive error, amblyopia, glaucoma, lost contact lenses, corneal abrasion/erosion, strabismus, and time and expenses associated with frequent office visits and optical correction replacement.
Archives of Ophthalmology - Mer, 14 Luglio 2010
http://archopht.ama-assn.org/
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Emergence of antibiotic-resistant bacteria is a consequence of increasing antibiotic selection pressure caused by the demand for new antibiotics for new and emerging infections, emergence of resistant organisms, inappropriate use of antibiotics in medical practice, and use of antibiotics in industry.
Archives of Ophthalmology - Mer, 16 Giugno 2010
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Biologic therapy may be broadly defined as treatment using an agonist or an antagonist to specifically enhance or suppress the level of a naturally occurring protein molecule to manipulate a disease state. Agonists used in biologic therapy include a variety of cytokines and growth factors. Antagonists include monoclonal antibodies and other agents capable of binding soluble and/or cell membrane–bound proteins.
Archives of Ophthalmology - Mar, 18 Maggio 2010
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In this issue of the Archives, Berson and colleagues1 report the results of a well-designed and well-executed clinical trial that extends their studies of the effects of nutritional supplements on the rate of progression of retinitis pigmentosa (RP).
Archives of Ophthalmology - Lun, 19 Aprile 2010
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For those of us of a certain age, conventional wisdom stated that elevated intraocular pressure (IOP) caused glaucoma, and lowering IOP was the only effective way to prevent and treat it.
Archives of Ophthalmology - Mar, 9 Marzo 2010
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Until the first half of the 20th century, few ophthalmologists in the United States specialized in the field of ocular oncology.
Archives of Ophthalmology - Mar, 9 Marzo 2010
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Toxoplasmosis is generally considered to be an endemic disease, the prevalence of which varies considerably in different geographic areas of the world. To be precise, the term toxoplasmosis refers to disease caused by the parasite Toxoplasma gondii, rather than simply infection per se, and in fact, most seropositive individuals have no history of systemic or ocular disease and have no idea when they became infected.
Archives of Ophthalmology - Lun, 1 Febbraio 2010
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