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Babies born to women with sensitivity to gluten appear to be at increased risk of developing schizophrenia and other psychiatric disorders later in life, according to new findings from Karolinska Institutet in Sweden and Johns Hopkins University, United States. Maternal infections and other inflammatory disorders during pregnancy have long been linked to a greater risk for schizophrenia in the offspring. However the current study, which will be published in the June issue of the American Journal of Psychiatry, is the first to point to maternal food sensitivity as a possible culprit in the development of such disorders later in life.
Karolinska Institutet - Mar, 15 Maggio 2012
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Researchers have analyzed past studies to investigate possible associations between maternal age and autism spectrum disorder. While much research has been done to identify potential genetic causes of autism, the current analysis suggests that non-heritable and environmental factors may also play a role in children's risk for autism.
Karolinska Institutet - Mer, 2 Maggio 2012
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Individuals with a sibling who has had a stroke have an increased risk of having one themselves - and often around the same age as their brother or sister. According to the researchers, this new knowledge further emphasizes the importance of health professionals paying attention to their patient's family history to prevent stroke.
The current findings, which are published in the scientific journal Circulation: Cardiovascular Genetics, come from the first large study to examine the combined influence of age, gender and sibling history on stroke risk.
Karolinska Institutet - Mar, 17 Aprile 2012
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Oesophageal cancer is a very serious form of cancer that, if not fatal, requires extensive surgery. A new study from Karolinska Institutet shows that when serious complications arise after surgery for oesophageal cancer, many patients suffer other health problems, such as breathlessness, fatigue, insomnia and eating problems, for five years afterwards.
Karolinska Institutet - Mar, 3 Aprile 2012
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A new study shows that a new drug for Huntington's disease - pridopidine or dopamine stabiliser ACR16 - might operate via previously unknown mechanisms of action. Researchers have found that at very low concentrations, ACR16 binds to the sigma-1 receptor, a protein in the brain important to neuronal function and survival. This new knowledge can be used to develop future treatments for schizophrenia, involuntary Parkinsonian tremors and neurodegenerative diseases.
Karolinska Institutet - Lun, 27 Febbraio 2012
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A team of researchers has generated a map over the effects of small drug-like molecules on PARP1 and other similar proteins in the body. This map may explain the mechanism behind putative side effects of the so-called PARP inhibitors, and can play an important role in the development of novel tailor-made cancer drugs. The study will hopefully contribute to new cancer therapies with fewer detrimental side effects.
Karolinska Institutet - Mar, 21 Febbraio 2012
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According to new research published in the British Journal of Cancer, eating too much processed meat may increase the risk of pancreatic cancer. The study found that for each 50 grams of processed meat eaten every day - equivalent to a sausage or two rashers of bacon - there was a 19 per cent rise in the risk of pancreatic cancer compared to those who ate no meat.
Karolinska Institutet - Mar, 24 Gennaio 2012
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A new study published in the Journal of Clinical Oncology shows that most patients who survive for at least five years after oesophageal cancer surgery recover an average quality of life. However, quality of life deteriorates significantly for one in six patients to a level that remains much lower than the average population in the five years after surgery. This suggests, say the researchers, that hospitals must be better at identifying this patient group.
Karolinska Institutet - Mar, 24 Gennaio 2012
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Researchers at Karolinska Institutet have demonstrated that a growth hormone, PDGF-BB, and the blood protein EPO are involved in the development of cancer tumours and that they combine to help the tumours proliferate in the body. These new preclinical findings offer new potential for inhibiting tumour growth and bypassing problems of resistance that exist with many drugs in current use. The results are published in the scientific journal Nature Medicine.
Karolinska Institutet - Mar, 6 Dicembre 2011
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Mothers who deliver low-birth weight infants are at increased risks of cardiovascular diseases (CVD) later in life. This according to a new study, published online in the science magazine Circulation.
Karolinska Institutet - Mar, 6 Dicembre 2011
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