Diabetologia 

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  • Is a Severe Clinical Profile an Effect Modifier in a Web-Based Depression Treatment for Adults With Type 1 or Type 2 Diabetes?

    Web-based diabetes-specific CBT depression treatment is suitable for use in patients with severe mental health problems and those with a less severe clinical profile. Data come from an International Standard Randomized Controlled Trial on the effectiveness of an eight-lesson Web-based, diabetes-specific CBT for depression.

    Journal of Medical Internet Research - JMIR (Diabetologia) - Mar, 24 Gennaio 2012
    http://www.jmir.org

  • Stem Cell Therapy May Reverse Diabetes

    An immune regulator from healthy cord blood stem cells (CB-SCs) can "educate" the T cells of a person with type 1 diabetes (T1D), enabling the pancreas to produce insulin, according to a report published online January 10, 2012, in BMC Medicine.

    Medscape (Diabetologia) - Mar, 17 Gennaio 2012
    http://www.medscape.com

  • The good and the bad of diabetes mellitus in the critically ill

    Diabetes mellitus is increasingly prevalent and associated with significant end organ damage that one may presume to impact upon critical illness. However, Siegelaar and colleagues present data that suggest, excepting those patients admitted to a cardiac intensive care unit (ICU), the presence of diabetes mellitus is not associated with increased mortality in critically ill patients.

    Critical Care (Diabetologia) - Mar, 13 Dicembre 2011
    http://ccforum.com

  • Large-Leaf Vegetables and Type 2 Diabetes

    It is well known that the intake of fruit and vegetables is associated with lower cardiovascular and cancer risks, but what about diabetes? In order to clear this doubt up, a meta-analysis has been performed on 6 prospective trials (average duration 13 years) involving over 200,000 subjects between 30 and 74 years of age.

    MedNews (Diabetologia) - Lun, 5 Dicembre 2011
    http://mn.medsurfnews.com/

  • Intensive therapy halves kidney disease in type 1 diabetes

    Controlling blood glucose early in the course of type 1 diabetes yields huge dividends, preserving kidney function for decades. The new finding from a study funded by the National Institutes of Health was published online in the New England Journal of Medicine Nov. 12 to coincide with presentation at a scientific meeting.

    National Institutes of Health (Diabetologia) - Mar, 15 Novembre 2011
    http://www.nih.gov

  • Weekly Exenatide

    In type 2 diabetes, you can use incretin-mimetic drugs to stimulate insulin secretion and mitigate glucagone release, slowing gastric emptying at the same time. Among these ones, exenatide (an agonist of glucagone-like peptide-1 ( GLP-1) receptors) needs one-two daily administrations, so a long-acting formulation is being studied, with a weekly administration. Sitagliptin (an inhibitor of dipeptidyl-peptidase-4) is based on a similar mechanism of action, slowing the degradation of endogenous GLP-1. This kind of drugs can represent therapeutical alternatives to sulfonylurea or to thiazolidinediones, when metformin alone is not capable to control diabetes.

    MedNews (Diabetologia) - Lun, 7 Novembre 2011
    http://mn.medsurfnews.com/

  • Poorly controlled diabetes 'bad to the bone'

    source of the diabetic nerve pain and degeneration begins with a special fusion of bone marrow and nerve cells that lead to nerve death and dysfunction – proving that diabetes is indeed "bad to the bone," said researchers from Baylor College of Medicine in two recent reports.

    Baylor College of Medicine (Diabetologia) - Mer, 19 Ottobre 2011
    http://www.bcm.edu

  • Pressure Control in Diabetics with Coronary Artery Disease

    In diabetic patients, the highest pressure limit has been established in a value under 130/80 mmHg, but can the presence of a coronary artery disease induce to different recommendations? Some researchers have analyzed the data collected with the INVEST trial (a randomized trial on people with hypertension and coronary artery disease, treated with beta-blockers or Ca-antagonists). Some previous conclusions had not recommended a too aggressive treatment of hypertension, verifying that in these patients it would have implied an excess in cardiovascular events.

    MedNews (Diabetologia) - Lun, 12 Settembre 2011
    http://mn.medsurfnews.com/

  • Obesity and Diabetes Risk

    It is well known that obesity and fat excess are factors predisposing to diabetes mellitus, but how can we quantify this association? A wide cohort trial has been used to monitor about 4,000 elderly (age ≥ 65) for a duration of averagely 12 years. During that period, 339 new cases of diabetes have been identified. Relating BMI with diabetes onset, it was seen that for subjects belonging to the higher quintile (in the division according to obesity), the risk to develop diabetes was 4 to 5 times higher than in subjects belonging to the lower quintile.

    MedNews (Diabetologia) - Lun, 12 Settembre 2011
    http://mn.medsurfnews.com/

  • Exenatide Versus Lantus

    In the therapeutic equipment of type-2 diabetics, exenatide has recently appeared, an agonist of glucagone-like peptide (GLP-1) receptors; its mechanism of action lies in the stimulus of glucose-dependent insulin secretion, in reducing glucagone secretion and in slowing down the period of gastric emptying, with the consequent decrease of food intake. The FDA has approved its daily formulation (two injections a day), but it was shown that a single weekly injection is more effective in reducing HbA1c and in obtaining weight loss.

    MedNews (Diabetologia) - Lun, 5 Settembre 2011
    http://mn.medsurfnews.com/

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