Risorse da Journal of the American Medical Association

  • Autologous Stem Cells in Kidney Transplants

    Immunosuppressive induction therapy—routine in organ transplants—reduces the risk of organ rejection but is associated with adverse effects. Infusion of bone marrow–derived mesenchymal stem cells, which have immunoregulatory effects, may offer an alternative immunosuppressive approach. In a randomized trial of 159 patients undergoing living-related kidney transplants, Tan and colleagues found that compared with conventional anti–interleukin 2 receptor antibody–based therapy, a regimen that involved infusion of autologous mesenchymal stem cells was associated with a lower incidence of acute rejection and better renal function at 1 year.

    Journal of the American Medical Association - Mar, 27 Marzo 2012
    http://jama.ama-assn.org/

  • Papules, Plaques, and Nodules in an Immunocompromised Patient

    An 85-year-old man is admitted for evaluation of multiple papules, plaques, and subcutaneous nodules on his face, trunk, and extremities. The patient has itching. There is no history of trauma. He has an 8-year history of diabetes and Sjögren syndrome with eye and mouth involvement and has been treated with varied doses of oral methylprednisolone for 5 years.

    Journal of the American Medical Association - Mar, 31 Gennaio 2012
    http://jama.ama-assn.org/

  • Clopidogrel on CYP2C19 Genotype and Effect on Platelet Reactivity in Patients With Stable Cardiovascular Disease

    Variants in the CYP2C19 gene influence the pharmacologic and clinical response to the standard 75-mg daily maintenance dose of the antiplatelet drug clopidogrel. A study tested whether higher doses (up to 300 mg daily) improve the response to clopidogrel in the setting of loss-of-function CYP2C19 genotypes.

    Journal of the American Medical Association - Mar, 22 Novembre 2011
    http://jama.ama-assn.org/

  • Association Between Disease-Modifying Antirheumatic Drugs and Diabetes Risk in Patients With Rheumatoid Arthritis and Psoriasis

    Rheumatoid arthritis (RA) and psoriasis have been linked with insulin resistance and diabetes mellitus (DM). Prior investigations suggest that systemic immunosuppressive drugs may improve insulin resistance and reduce the risk of DM.

    Journal of the American Medical Association - Mer, 22 Giugno 2011
    http://jama.ama-assn.org/

  • Interactive Games to Promote Behavior Change in Prevention and Treatment

    Games are now a dominant form of media, even larger than the motion picture industry, and are enjoyed across gender, age, and cultural boundaries. Games targeting healthy behaviors are also proliferating. Such games deserve serious attention, because clinicians and policy makers will be confronted with decisions regarding their use. There is great promise in channeling these hours of engagement to address some of the most difficult and persistent challenges involving diet, exercise, and adherence to therapy. Sufficiently engaging games might enhance the effectiveness of health messaging, allowing individuals to practice useful thought patterns and behaviors and encouraging them to explore and learn from failure in safe virtual environments.

    Journal of the American Medical Association - Lun, 4 Aprile 2011
    http://jama.ama-assn.org/

  • Mediastinoscopy vs Endosonography for Mediastinal Nodal Staging of Lung Cancer: A Randomized Trial

    Among patients with (suspected) NSCLC, a staging strategy combining endosonography and surgical staging compared with surgical staging alone resulted in greater sensitivity for mediastinal nodal metastases and fewer unnecessary thoracotomies.

    Journal of the American Medical Association - Mer, 1 Dicembre 2010
    http://jama.ama-assn.org/

  • Association Between Familial Atrial Fibrillation and Risk of New-Onset Atrial Fibrillation

    In a a prospective community-based cohort study started in 1948, familial AF was associated with an increased risk of AF that was not attenuated by adjustment for AF risk factors including genetic variants. Assessment of premature familial AF was associated with a very slight increase in predictive accuracy compared with traditional risk factors.

    Journal of the American Medical Association - Mer, 1 Dicembre 2010
    http://jama.ama-assn.org/

  • Current Depression Among Adults — United States, 2006 and 2008

    Estimate the prevalence of current depression, CDC analyzed Behavioral Risk Factor Surveillance System (BRFSS) survey data from 2006 and 2008.

    Journal of the American Medical Association - Mar, 30 Novembre 2010
    http://jama.ama-assn.org/

  • Current Depression Among Adults — United States, 2006 and 2008

    Estimate the prevalence of current depression, CDC analyzed Behavioral Risk Factor Surveillance System (BRFSS) survey data from 2006 and 2008.

    Journal of the American Medical Association - Mar, 30 Novembre 2010
    http://jama.ama-assn.org/

  • FDA Promotes Safer Use of Analgesics in Older Adults With Chronic Pain

    Pain, a common complaint for elderly patients, can be challenging for physicians to treat safely and effectively. To better understand these challenges and to promote safer use, the US Food and Drug Administration (FDA) has recently begun examining pain medication use in elderly patients as part of its Safe Use Initiative.

    Journal of the American Medical Association - Mar, 9 Novembre 2010
    http://jama.ama-assn.org/
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