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The diagnosis of osteoporosis and its consequent pharmacological treatment are based on T-score assessment, obtained through DEXA. In recent times, prediction models of fracture risk at 10 years have been created and researchers have tried to see how these predictions can influence the use of pharmacological therapy.
MedNews - Lun, 21 Maggio 2012
http://mn.medsurfnews.com/
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Since there is still a little bit of uncertainty on the use of clopidogrel together with protonic pump inhibitors (PPIs), a consensus document has been published by the American College of Cardiology, by the American College of Gastroenterology and by the American Heart Association. We know that clopidogrel is competitively inhibited by PPIs. Its action in reducing platelet aggregation is then antagonized by PPIs, even if clinically we do not know well which is the extent of this inhibition.
MedNews - Lun, 21 Maggio 2012
http://mn.medsurfnews.com/
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According to both animal studies and human studies, it results that renal sympathetic denervation, performed through catheter, is capable to decrease blood pressure resistant to usual treatments. In the first randomized trial on this technique (sponsored by the producer of the used catheter), 106 patients with resistant hypertension (systolic pressure ≥ 160 mmHg in non-diabetic subjects and systolic pressure ≥ 150 mmHg in diabetics, all under treatment with at least three anti-hypertension drugs) have been randomized to undergo sympathetic catheterism.
MedNews - Lun, 21 Maggio 2012
http://mn.medsurfnews.com/
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We know, from previous trials, that cardiovascular risk decreases in a linear way with the reduction of LDL cholesterol, obtained through statin administration (for example, CV risk decreases of 20% for each reduction of 40 mg/dl in LDL cholesterol).
MedNews - Lun, 14 Maggio 2012
http://mn.medsurfnews.com/
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In the RE-LY study, on patients affected by atrial fibrillation and with a stroke risk, the administration of dabigatran (an oral inhibitor of thrombin) has reduced the risk of stroke and has presented a bleeding risk superimposable to the ones of warfarin.
MedNews - Lun, 14 Maggio 2012
http://mn.medsurfnews.com/
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The generalized anxiety disorder (GAD) is a chronic disease needing long-term treatments. In order to verify the obtainable benefit with a 6-month and a 12-month therapy through long-term-release venlafaxine, 268 subjects with a diagnosis of GAD have been treated through an open-label study: after 6 months of venlafaxine treatment, improved patients have been randomized to receive 6 further months of venlafaxine or placebo.
MedNews - Lun, 14 Maggio 2012
http://mn.medsurfnews.com/
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In the treatment of thrombocytopenic purpura, the used drugs are the ones capable to stimulate platelet production, even if these products, even obtaining an increase in the number of platelets, are not often capable to reach clinically significant results, antagonized as they are by the increased platelet destruction, typical of purpura.
MedNews - Lun, 7 Maggio 2012
http://mn.medsurfnews.com/
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Dabigatran is an inhibitor of thrombin, authorized for its use in the prevention of stroke in patients with atrial fibrillation, showing the efficacy and the safety of warfarin but with some advantages compared to this one. The great problem of dabigatran is however represented by the cost-efficacy relation.
MedNews - Lun, 7 Maggio 2012
http://mn.medsurfnews.com/
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For the treatment of postmenopausal and of cortisone-related osteoporosis, the primary role is kept by bisphosphonates, even if some studies have suggested a possible link between the continued use of these molecules and the onset of low-energy hip fractures (subtrochanteric or diaphisary ones), a consequence of an interference with bone reabsorption.
MedNews - Lun, 7 Maggio 2012
http://mn.medsurfnews.com/
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One of the questions with no answer is the one relative to survival in patients with an advanced stage of dementia, and the answer to this question often influences the decisions of possible hospitalizations in palliative care structures. With a prospective study, the prevision of death among 606 patients hospitalized in a protected structure in Massachusetts have been examined, according to two parameters: the ADEPT (Advanced Dementia Prognostic Tool) score, an evaluation scale including 12 factors, among which age, presence of trophic ulcers, incontinence, recent weight loss, where the scale ranges from 1 to 32.5 points and where the highest score indicates a lower survival.
MedNews - Mer, 2 Maggio 2012
http://mn.medsurfnews.com/