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Cardiologia
Cancer treatment today employs a combination of chemotherapy, radiotherapy, and surgery to prolong life and provide cure. However, many of these treatments can cause cardiovascular complications such as heart failure, myocardial ischemia/infarction, hypertension, thromboembolism, and arrhythmias.
Journal of the American College of Cardiology - Ven, 12 Giugno 2009
http://content.onlinejacc.org/
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Cardiologia
Acute heart failure syndromes (AHFS) remain a major cause of morbidity and mortality, in part because the development of new therapies for these disorders has been marked by frequent failure and little success. The heterogeneity of current approaches to AHFS drug development, particularly with regard to end points, remains a major potential barrier to progress in the field..
Journal of the American College of Cardiology - Ven, 12 Giugno 2009
http://content.onlinejacc.org/
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Genetica e Malattie Rare
A team of Johns Hopkins scientists has catalogued chemical tags attached to more than 800 genes from 76 human brain samples and collected the first evidence of how these special, inherited epigenetic “marks” might account for different brain functions. The results appear in the December issue of The American Journal of Human Genetics.
Johns Hopkins Hospital - Ven, 12 Giugno 2009
http://www.hopkinshospital.org
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Diabetologia
The prevalence of diabetes mellitus is rising at an alarming rate and is projected to more than double by 2030. The disease currently afflicts 171 million people worldwide, with 23.6 million in the United States. The adverse microvascular and macrovascular consequences of diabetes are well recognized, as is the accompanying accelerated rate of atherosclerosis that predisposes patients to coronary artery disease and to higher rates of myocardial infarction and death.
New England Journal of Medicine - Ven, 12 Giugno 2009
http://www.nejm.org
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Ortopedia
New EULAR recommendations for the diagnosis of knee osteoarthritis focus on simple measures, including clinical examination and plain radiography.
Medscape - Ven, 12 Giugno 2009
http://www.medscape.com
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Genetica e Malattie Rare
Despite several observational studies showing that lipoprotein(a) is associated with myocardial infarction (MI), only circumstantial evidence exists regarding the causal nature of this association. Observational epidemiological studies, even with a sound prospective design, can provide hints to disease pathogenesis when the effect size is modest but cannot provide definitive evidence for causal relationships.
Journal of the American Medical Association - Ven, 12 Giugno 2009
http://jama.ama-assn.org/
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Oftalmologia
It is not an exaggeration to describe the current practice environment for ophthalmologists caring for neonates at risk for retinopathy of prematurity (ROP) as a crisis; there are increasing liability claims and judgments against ophthalmologists for ROP and a worsening scarcity of ophthalmologists willing to treat ROP.
Archives of Ophthalmology - Ven, 12 Giugno 2009
http://archopht.ama-assn.org/
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Geriatria
A major objective in designing a randomized clinical trial is to minimize bias in the assessment of the study's primary outcome. Although we often think of bias as referring to the situation where a difference between treatment groups is found that is not real, bias also can prevent a study from finding a true treatment group difference. The former situation is referred to as differential bias and the latter as nondifferential bias.
Archives of Ophthalmology - Ven, 12 Giugno 2009
http://archopht.ama-assn.org/
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Psichiatria
Unlike the health of our bodies, the health of our minds is often neglected. In 2007, The Lancet's Series on Global Mental Health sought to draw attention to the worldwide burden of mental illness. Data published by Michael Phillips and colleagues in this issue indicate that mental health disorders might affect far more people than previously estimated.
The Lancet - Ven, 12 Giugno 2009
http://www.thelancet.com
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Farmacologia
Almost 2 billion people worldwide lack access to essential medicines. The human rights responsibility to improve access lies mainly with the state. However, non-state actors, such as the pharmaceutical industry, share that responsibility too.
The Lancet - Ven, 12 Giugno 2009
http://www.thelancet.com