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Ematologia
Thalidomide was introduced for multiple myeloma (MM) in 1998. Its mode of action makes it a suitable candidate to combine with corticosteroids. Hence, it has been combined with dexamethasone or melphalan/prednisolone (MP) as upfront treatment for patients who are not eligible for high-dose therapy.
Blood - Ven, 10 Aprile 2009
http://www.bloodjournal.org/
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Dietologia e nutrizione
Certain ethnic groups may not be getting accurate estimates of disease risk when they try to determine obesity using the traditional body mass index scale, say researchers at Baylor College of Medicine and the University of Houston in a study in the current edition of British Journal of Nutrition. DXA images are of two adults with the same BMI.
Baylor College of Medicine - Ven, 10 Aprile 2009
http://www.bcm.edu
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Psichiatria
Older adults with generalized anxiety disorder who received cognitive behavior therapy had greater improvement on measures of worry, depression and mental health than patients who received usual care, according to a study in the April 8 issue of JAMA.
Baylor College of Medicine - Ven, 10 Aprile 2009
http://www.bcm.edu
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Pediatria
Childhood obesity is a complex problem that intrigues and sometimes frustrates those trying to prevent it. A positive result of this challenge is that it has brought together talented scholars from diverse disciplines, ranging from architecture, to neuroscience, to social work.
Archives of Pediatrics & Adolescent Medicine - Ven, 10 Aprile 2009
http://archpedi.ama-assn.org/
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Pediatria
Cardiovascular disease is the number one cause of mortality in the adult population of the United States.1 Much of this is due to atherosclerotic cardiovascular disease. Recognition of these facts has led to national guidelines to control risk factors for cardiovascular disease, such as type 2 diabetes mellitus, dyslipidemia, and hypertension, and to the concept that recognition, treatment, and control of risk factors are important to prevent cardiovascular disease morbidity and mortality.
Archives of Pediatrics & Adolescent Medicine - Ven, 10 Aprile 2009
http://archpedi.ama-assn.org/
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Oncologia
The FDA has approved the use of Afinitor for patients whose advanced renal cell cancer is no longer responding to Sutent (sunitinib) or Nexavar (sorafenib).
American Cancer Society - Ven, 10 Aprile 2009
http://www.cancer.org/
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Psichiatria
Functional magnetic resonance imaging (fMRI) adaptation has become increasingly popular in cognitive neuroscience and has the power to provide insight into how subpopulations of neurons within a small area selectively respond to similar or different types of stimuli or experimental manipulations.
American Journal of Psychiatry - Ven, 10 Aprile 2009
http://ajp.psychiatryonline.org/
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Psichiatria
The genetics of schizophrenia has many hurdles to overcome. The illness is complex, with the likely involvement of multiple genes, each giving rise to subtle, often unknown alterations in brain function, and each interacting with multiple environmental factors.
American Journal of Psychiatry - Ven, 10 Aprile 2009
http://ajp.psychiatryonline.org/
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Psichiatria
The article in this issue by Rottman and colleagues (1) is timely. It significantly informs the current debate about how to improve the representation of personality disorders in DSM by comparing two proposed alternative models of assessment on their clinical utility.
American Journal of Psychiatry - Ven, 10 Aprile 2009
http://ajp.psychiatryonline.org/
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Cardiologia
Statins lower high-sensitivity C-reactive protein (hsCRP) and cholesterol concentrations, and hypothesis generating analyses suggest that clinical outcomes improve in patients given statins who achieve hsCRP concentrations less than 2 mg/L in addition to LDL cholesterol less than 1ยท8 mmol/L (<70 mg/dL). However, the benefit of lowering both LDL cholesterol and hsCRP after the start of statin therapy is controversial. We prospectively tested this hypothesis.
The Lancet - Ven, 10 Aprile 2009
http://www.thelancet.com