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To determine the incidence of any and referable diabetic retinopathy in people with type 2 diabetes mellitus attending an annual screening service for retinopathy a a retrospective four year analysis has been performed. The analysis supports the extension of the screening interval for people with type 2 diabetes mellitus beyond the currently recommended 12 months, with the possible exception of those with diabetes duration of 10 years or more and on insulin treatment.
British Medical Journal - Mar, 28 Febbraio 2012
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A meta-analysis of randomised controlled trials with data extraction and quality assessment performed independently by two researchers systematically evaluated the effects of physical activity in adult patients after completion of main treatment related to cancer.
British Medical Journal - Mar, 7 Febbraio 2012
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A 53 year old man attends for a routine check-up. He underwent coronary artery bypass grafting after a myocardial infarction earlier in the year, and seems to be making good progress. He says he needs to discuss an embarrassing problem. He explains that he has been having erectile dysfunction, which is making him miserable and preventing normal marital relations.
British Medical Journal - Mar, 26 Luglio 2011
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To determine the comparative effects of the thiazolidinediones (rosiglitazone and pioglitazone) on myocardial infarction, congestive heart failure, and mortality in patients with type 2 diabetes, a systematic review and meta-analysis of observational studies was performed. Results showed that, among patients with type 2 diabetes, use of rosiglitazone is associated with significantly higher odds of congestive heart failure, myocardial infarction, and death relative to pioglitazone in real world settings.
British Medical Journal - Lun, 21 Marzo 2011
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To appraise the evidence for comparative efficacy and tolerability of drug treatments in patients with generalised anxiety disorder, a systematic review has been performed. Primary Bayesian probabilistic mixed treatment meta-analyses allowed pharmacological treatments to be ranked for effectiveness for each outcome measure, given as percentage probability of being the most effective treatment. Secondary frequentist mixed treatment meta-analyses conducted with random effects model; effect size reported as odds ratio and 95% confidence interval. Analyses compared nine drugs (duloxetine, escitalopram, fluoxetine, lorazepam, paroxetine, pregabalin, sertraline, tiagabine, and venlafaxine). Though the frequentist analysis was inconclusive because of a high level of uncertainty in effect sizes (based on the relatively small number of comparative trials), the probabilistic analysis, which did not rely on significant outcomes, showed that fluoxetine (in terms of response and remission) and sertraline (in terms of tolerability) seem to have some advantages over other treatments. Among five UK licensed treatments, duloxetine, escitalopram, and pregabalin might offer some advantages over venlafaxine and paroxetine.
British Medical Journal - Lun, 14 Marzo 2011
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To systematically determine the impact of growth hormone therapy on adult height of children with idiopathic short stature, a systematic review of the Cochrane Central Register of Controlled Trials, Medline, and the bibliographic references from retrieved articles of randomised and non-randomised controlled trials from 1985 to April 2010 has been performed. The analysis showed that Growth hormone therapy in children with idiopathic short stature seems to be effective in partially reducing the deficit in height as adults, although the magnitude of effectiveness is on average less than that achieved in other conditions for which growth hormone is licensed. The individual response to therapy is highly variable, and additional studies are needed to identify the responders.
British Medical Journal - Lun, 14 Marzo 2011
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Remote healthcare technologies may reduce the number of emergency admissions to hospital among patients with certain long term conditions such as chronic obstructive pulmonary disease (COPD), show preliminary results from a large randomised controlled trial of such technology.
British Medical Journal - Lun, 7 Marzo 2011
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A case study investigating hyponatraemia presence in a 70 year old woman with chronic obstructive pulmonary disease.
British Medical Journal - Lun, 7 Marzo 2011
http://www.bmjjournals.com
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Early recognition and early aggressive treatment of juvenile idiopathic arthritis prevent joint damage and allow for normal development and growth.
The disease is heterogeneous and complex, so patients benefit from regular review and management by experts in a multidisciplinary team.
British Medical Journal - Lun, 6 Dicembre 2010
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Epilepsy is the most common neurological disorder seen in pregnant women. It often needs drug treatment, and it causes complications in about 0.25% of all pregnancies.
British Medical Journal - Lun, 6 Dicembre 2010
http://www.bmjjournals.com