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According to previously performed trials, it was hypothesized that the discontinuation of a protonic pump inhibitor (PPI) can cause a rebound of acid hyper secretion, due to an increase, provoked by the PPI, of plasmatic gastrin, which, in its turn, stimulates gastric cells. When the PPI is interrupted, these cells would undergo a stimulation and would increase the production of acid. In order to verify the clinical aspect of this phenomenon, some researchers in Denmark have performed a double-blind randomized trial involving 120 healthy volunteers with no previous event of dyspepsia and pyrosis: participants received a 12-week treatment with placebo or an 8-week treatment with esomeprazole (40 mg/die), followed by 4 weeks with placebo.
MedNews (Gastroenterologia) - Lun, 1 Febbraio 2010
http://mn.medsurfnews.com/
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Rotavirus is the leading cause of gastroenteritis in children worldwide. In this report, the efficacy of the rotavirus vaccine among 4417 children in Malawi and South Africa was studied in a randomized trial. Severe rotavirus gastroenteritis occurred in 4.9% of the infants in the placebo group as compared with 1.9% of the infants in the pooled vaccine group; the vaccine efficacy was 61.2%.
New England Journal of Medicine (Gastroenterologia) - Lun, 1 Febbraio 2010
http://www.nejm.org
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Laparoscopic total gastrectomy for advanced gastric cancer is an approach that has been developing since 1999, when it was first described by Azagra et al1 and Uyama et al.2 In this article, Shinohara et al show an expertise and technical skill with outcomes and lymphadenectomy comparable to those of open total gastrectomies.
Archives of Surgery (Gastroenterologia) - Ven, 15 Gennaio 2010
http://archsurg.ama-assn.org/
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Drinking warm water in advance seems to improve the comfort of colonoscopy, as well as the completeness of the procedure, hint findings of a study from Korea.
Medscape (Gastroenterologia) - Gio, 7 Gennaio 2010
http://www.medscape.com
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In this issue of the Journal, Glocker et al.1 provide the first substantial support for a functional role for the immunosuppressive cytokine interleukin-10 in the pathogenesis of inflammatory bowel disease.
New England Journal of Medicine (Gastroenterologia) - Mar, 24 Novembre 2009
http://www.nejm.org
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Gastroparesis — Comprehensive overview covers symptoms, treatment, diet for this digestive condition.
MayoClinic.com (Gastroenterologia) - Mar, 24 Novembre 2009
http://www.mayoclinic.com
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We performed genetic-linkage analysis and candidate-gene sequencing on samples from two unrelated consanguineous families with children who were affected by early-onset inflammatory bowel disease. We screened six additional patients with early-onset colitis for mutations in two candidate genes and carried out functional assays in patients' peripheral-blood mononuclear cells. We performed an allogeneic hematopoietic stem-cell transplantation in one patient.
New England Journal of Medicine (Gastroenterologia) - Ven, 6 Novembre 2009
http://www.nejm.org
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Noroviruses are now recognized as the leading cause of epidemics of gastroenteritis and an important cause of sporadic gastroenteritis among both children and adults. In the United States, more than 90% of the outbreaks of gastroenteritis for which the cause could not previously be identified can now be attributed to this virus. Understanding the nature of immunity to the norovirus is a key determinant for future improvements in the control and prevention of this viral infection.
New England Journal of Medicine (Gastroenterologia) - Ven, 30 Ottobre 2009
http://www.nejm.org
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Through a multicentric trial sponsored by pharmaceutical industry, 764 adults affected by bleeding gastric or duodenal ulcer have been treated with a high dose of intravenously infused esomeprazole or placebo. All patients presented endoscopic signs of recent bleeding and almost all of them had been endoscopically treated (local injective therapy, ulcer coagulation or both treatments).
MedNews (Gastroenterologia) - Lun, 26 Ottobre 2009
http://mn.medsurfnews.com/
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Celiac disease develops in genetically predisposed individuals as a response to ingested gluten. Gluten is the term for the storage proteins of the cereal grains wheat, rye, and barley. While virtually 100% of the population ingests these grains in one form or another and 30% to 40% of the population carry the genetic markers of the disease (HLA-DQ2 or type 8), only 2% to 3% of those with genetic markers develop the disease.
Journal of the American Medical Association (Gastroenterologia) - Ven, 18 Settembre 2009
http://jama.ama-assn.org/