Absent Toll-like receptor-9 expression predicts poor prognosis in renal cell carcinoma

Toll-like receptor 9 (TLR9) is a cellular DNA-receptor whose activation with cognate ligands triggers an immune reaction, with increased production of inflammatory cytokines. The aim of this study was to examine the expression of TLR9 in renal cell carcinoma (RCC), which is generally renowned of its immunogenic nature. TLR9 expression resulted as an independent prognostic marker of RCC and the absence of TLR9 expression is related to poorer prognosis in RCC.

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