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Brachial artery hyperemic velocity may be a useful measurement to identify patients who could benefit from novel therapies designed to reverse microvascular dysfunction in severe sepsis, and to assess the physiologic efficacy of these treatments.
Critical Care - Mar, 13 Marzo 2012
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Power injectable peripherally inserted central catheters can be used successfully in most intensive care unit patients with few contraindications and low rates of complications, similar to central venous catheters (CVC).
Critical Care - Mar, 7 Febbraio 2012
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Reducing duration of antibiotic therapy without a diminution in efficacy decreases cost, side effects, antibiotic related diarrhoea, and bacterial resistance. A letter summarizes various obtained results.
Critical Care - Mar, 10 Gennaio 2012
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Diabetes mellitus is increasingly prevalent and associated with significant end organ damage that one may presume to impact upon critical illness. However, Siegelaar and colleagues present data that suggest, excepting those patients admitted to a cardiac intensive care unit (ICU), the presence of diabetes mellitus is not associated with increased mortality in critically ill patients.
Critical Care - Mar, 13 Dicembre 2011
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This review article focuses on potentially relevant pathophysiological elements in the development of ACLF and points out some promising treatment modalities in ACLF.
Critical Care - Mar, 25 Ottobre 2011
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Besides being non-invasive, urine sTREM-1 testing is more sensitive than testing WBC, serum CRP, and serum PCT for the early diagnosis of sepsis, as well as for dynamic assessments of severity and prognosis. It can also provide an early warning of possible secondary AKI in sepsis patients.
Critical Care - Mar, 25 Ottobre 2011
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Donnino et al. provide new insights into the field of oxidative stress and mitochondrial dysfunction during septic shock. These authors suggest a Coenzyme Q10 (CoQ10) deficiency in septic shock patients. Larger prospective observational trials measuring CoQ10 in septic shock patients are required to confirm the possibility of CoQ10 depletion. This study is a new step towards a study testing Coenzyme Q10 as a potential therapeutic agent for patients in septic shock.
Critical Care - Mar, 11 Ottobre 2011
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A discussion about a retrospective analysis showing that dobutamine use in patients undergoing cardiac surgery was independently associated with a 2.3-fold increase in mortality and a 2.7-fold increase in risk of renal dysfunction.
Critical Care - Mar, 27 Settembre 2011
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Circulating cell-free DNA (cf-DNA) mainly comes from apoptotic cells and can reflect the extent of cellular damage. Increased plasma levels of cf-DNA have been found in many acute disorders, including septic and clinically ill patients, and usually correlate well with clinical outcome. A study reported that levels of cf-DNA in plasma can be a prognostic marker in patients needing mechanical ventilation...
Critical Care - Lun, 12 Settembre 2011
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