Allergologia

Effects of Anti-IL-13 on nasal allergen challenge

In an upcoming issue of The Journal of Allergy and Clinical Immunology (JACI), Nicholson et al evaluated the effects of an anti-IL-13 blocking antibody compared with placebo on repeated nasal allergen challenge (NAC) responses in hay fever patients out of season. Nasal challenge models with serial non-invasive sampling have considerable potential to study the molecular basis of mucosal inflammatory responses. The authors conclude that nasal challenge models can also be used to predict responders and monitor effects of specific therapy for allergy and asthma.
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American Academy of Allergy, Asthma and Immunology