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Gastroenterology
A 68-year-old woman with severe postmenopausal osteoporosis was referred because of a 6-month history of erosive mucositis of the hard palate, accompanied by intense pain and dysphagia.
New England Journal of Medicine - Thu, 30 November 2006
http://www.nejm.org
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Orthopaedics
A 54-year-old man with a 3-year history of IgG myeloma, complicated by hypercalcemia, who was being treated with dexamethasone, lenalidomide, filgrastim, darbepoetin alfa, and pamidronate, presented with a 1-month history of severe bilateral jaw pain.
New England Journal of Medicine - Thu, 30 November 2006
http://www.nejm.org
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Orthopaedics
Nitrogen-containing bisphosphonates are used widely for the management of metastatic cancer in bone (intravenous zoledronic acid or pamidronate), for the prevention and treatment of osteoporosis (oral alendronate, risedronate, and ibandronate and intravenous ibandronate), for the treatment of Paget's disease of bone (intravenous pamidronate and oral alendronate and risedronate), and for the short-term management of acute hypercalcemia (intravenous zoledronic acid and pamidronate).
New England Journal of Medicine - Thu, 30 November 2006
http://www.nejm.org
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General medicine
In this survey of institutional review board (IRB) members, 36% of those surveyed reported having relationships with industry. Although 86% believed that such relationships never adversely affected IRB-related decisions, a small number acknowledged that they had voted on a protocol sponsored by a company or a competitor to a company with which they had an association.
New England Journal of Medicine - Thu, 30 November 2006
http://www.nejm.org
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General medicine
In this survey of patients enrolled in cancer trials, most were not worried about possible financial ties between researchers or medical centers and drug companies. Many patients wanted to be informed about financial ties or about the oversight system to protect against conflicts of interest, but few thought knowledge of financial ties would have influenced their decision to participate in the trial.
New England Journal of Medicine - Thu, 30 November 2006
http://www.nejm.org
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Orthopaedics
Skeletal progenitor cells differentiate into cartilage cells when one master gene actually suppresses the action of another, said Baylor College of Medicine researchers in a report that appears online in the journal Proceedings of the National Academy of Sciences.
Baylor College of Medicine - Wed, 29 November 2006
http://www.bcm.edu
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Cardiology
A longer infusion time for anthracycline administration appears to reduce the risk of cardiac failure, suggests a new review.
Medscape - Wed, 29 November 2006
http://www.medscape.com
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Oncology
An international consensus conference called for an expanded role of needle biopsies, sentinel lymph node biopsy, and less invasive procedures.
Medscape - Wed, 29 November 2006
http://www.medscape.com
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Pediatrics
The new statement no longer recognized side sleeping as a reasonable alternative to fully supine sleeping and stressed the need to avoid redundant soft bedding and bed sharing.
Medscape - Wed, 29 November 2006
http://www.medscape.com
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Rheumatology
Infliximab has been shown to be effective in the treatment of ankylosing spondylitis (AS) when treated in a dose of 5 mg/kg at 6 weekly intervals. This dose of infliximab has not been determined by any structured randomized trials and has significant cost implications. We describe our experience of treating AS with low-dose infliximab (3mg/kg at 8 weekly intervals). The efficacy and cost implications are discussed.
Rheumatology - Wed, 29 November 2006
http://rheumatology.oxfordjournals.org/