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Using primary human vascular endothelial cells grown on a surface coated with a basement membrane extract, authors found that infection with human herpesvirus 8 (HHV-8, or Kaposi sarcoma–associated herpesvirus) induces the formation of capillary-like tubules that are a hallmark of angiogenesis.
Blood (Hematology) - Mon, 2 April 2007
http://www.bloodjournal.org/
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The CD28 T-cell costimulatory molecule was shown to regulate in vivo migration of memory T cells independent of TCR stimulation, suggesting that CD28 can have additional functions beyond costimulation. However, the mechanism involved, the physiological relevance, and the therapeutic implications await further investigation.
Blood (Hematology) - Mon, 2 April 2007
http://www.bloodjournal.org/
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It is not certainly established yet which is the optimal level of haemoglobin in patients with chronic renal failure (CRF); now, two new randomized studies, sponsored by pharmaceutical industry producing erythropoietin, have tried to answer the question.
MedNews (Hematology) - Tue, 27 March 2007
http://mn.medsurfnews.com/
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The longest follow-up study ever done on children with acute lymphoblastic leukemia, supported in part by NIGMS, identifies risks for survivors later in life.
National Institute of General Medical Sciences (Hematology) - Wed, 21 March 2007
http://www.nigms.nih.gov/
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Little is known about the incidence of secondary neoplasms after 15 to 20 years in children and adolescents who were treated for acute lymphoblastic leukemia.
Journal of the American Medical Association (Hematology) - Wed, 21 March 2007
http://jama.ama-assn.org/
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To identify novel autoantibodies in acquired aplastic anemia (AA), we screened the sera of patients with AA possessing small populations of paroxysmal nocturnal hemoglobinuria (PNH)–type cells for the presence of antibodies (Abs) which recognize proteins derived from a leukemia cell line, UT-7.
Blood (Hematology) - Fri, 9 March 2007
http://www.bloodjournal.org/
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As no appeals against its draft recommendations were received, the National Institute for Health and Clinical Excellence (NICE) has today published its guidance on the use of fludarabine monotherapy for the treatment of chronic lymphocytic leukaemia (CLL). The guidance does not recommend the use of fludarabine monotherapy for first line treatment of CLL.
National Institute for Health and Clinical Excellence (Hematology) - Thu, 1 March 2007
http://www.nice.org.uk
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Studies in the 1970s and 1980s suggested that the outcome of childhood acute lymphoblastic leukaemia (ALL) could be improved by intensification of conventional continuation chemotherapy with pulses of vincristine sulfate and steroids.
The Lancet (Hematology) - Wed, 17 January 2007
http://www.thelancet.com
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Imatinib has transformed the treatment of chronic myeloid leukemia, but a subset of patients develop resistance to the drug. Researchers are exploring possible alternatives and are flagging nilotinib and dasatinib as 2 potentials.
Medscape (Hematology) - Tue, 16 January 2007
http://www.medscape.com