Hematology 

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  • Standards for adult sickle cell disease aim to reduce gaps in care

    Adults with acute crises caused by sickle cell disease should start analgesia within 30 minutes of arrival at hospital, be assessed for potentially life threatening complications, and be seen by specialist staff.

    British Medical Journal (Hematology) - Thu, 17 July 2008
    http://www.bmjjournals.com

  • NICE issues guidance on the use of erythropoietin analogues for anaemia induced by cancer treatment

    The National Institute for Health and Clinical Excellence (NICE) has published guidance on the use of epoetin (alpha and beta) and darbepoetin for the treatment of cancer-treatment induced anaemia.

    National Institute for Health and Clinical Excellence (Hematology) - Wed, 18 June 2008
    http://www.nice.org.uk

  • Blood Glucose Variability Predicts ICU Deaths

    Better management of blood glucose is needed in critically ill patients.

    Medscape (Hematology) - Thu, 22 May 2008
    http://www.medscape.com

  • Randomized Trials in Hemodialysis Patients

    Hemodialysis requires a reliable conduit to transport blood from the patient to the dialysis apparatus and back again, which is usually termed "vascular access."

    Journal of the American Medical Association (Hematology) - Thu, 15 May 2008
    http://jama.ama-assn.org/

  • Diagnosis and Prognosis in Acute Myeloid Leukemia

    The discovery, during the past 15 years, of acquired mutations and alterations in gene expression in the leukemic cells in all varieties of AML has not only changed the role of the microscope in diagnosing leukemia but also influenced the management of these diseases and how we think about their causes.

    New England Journal of Medicine (Hematology) - Sat, 3 May 2008
    http://www.nejm.org

  • Developments in acute lymphoblastic leukaemia

    Acute lymphoblastic leukaemia (ALL) affects both children and adults alike, with peak prevalence between the ages of 2 and 5 years. Authors of a Seminar review advances in both the fundamental understanding and clinical management of ALL in children and adults.

    The Lancet (Hematology) - Thu, 27 March 2008
    http://www.thelancet.com

  • Developments in chronic lymphocytic leukaemia

    A second Seminar says chronic lymphocytic leukaemia (CLL)—the most common form of leukaemia in Europe and North America—has a variable course, with survival ranging from months to decades.

    The Lancet (Hematology) - Thu, 27 March 2008
    http://www.thelancet.com

  • Treatment and prognostic impact of transient leukemia in neonates with Down syndrome

    Approximately 10% of the neonates with Down syndrome (DS) exhibit a unique transient leukemia (TL). Though TL resolves spontaneously in most patients, early death and development of myeloid leukemia (ML-DS) may occur. Prognostic factors as well as treatment indication are currently uncertain.

    Blood (Hematology) - Wed, 12 March 2008
    http://www.bloodjournal.org/

  • Natural History of Amyloidosis

    Systemic amyloidosis occurs in two main variations: AL (primary amyloidosis, associated with the presence of a monoclonal variation of plasmacells) and AA (amyloidosis secondary to chronic inflammatory diseases).

    MedNews (Hematology) - Sun, 20 January 2008
    http://mn.medsurfnews.com/

  • Iron-Overload–Related Disease in HFE Hereditary Hemochromatosis

    In this large, prospective study of persons of northern European ancestry living in Australia, 1 in 146 was homozygous for a mutation (C282Y) in the HFE gene that is associated with hereditary hemochromatosis. Disease related to iron overload developed in 28% of male homozygotes but in only 1% of female homozygotes.

    New England Journal of Medicine (Hematology) - Thu, 17 January 2008
    http://www.nejm.org

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