Resources from Arthritis Research & Therapy
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Results of a recent study may demonstrate a novel mechanism by which synovial inflammation can be initiated in patients with OA and how this process may contribute to the pathogenesis of OA joint pathology.
Arthritis Research & Therapy - Tue, 13 March 2012
http://arthritis-research.com/
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To test the hypothesis that hyperuricemia is associated with coronary artery calcification (CAC) among a relatively healthy population, and that the extent of calcification is directly proportional to the serum uric acid (sUA) concentration, data from 2,498 participants in the Coronary Artery Risk Development in Young Adults (CARDIA) study were analyzed. results showed that yperuricemia appears to be an independent risk factor for subclinical atherosclerosis in young adults.
Arthritis Research & Therapy - Mon, 18 April 2011
http://arthritis-research.com/
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As the immunosuppressive potency of 15-deoxyspergualin (DSG) has been shown in the therapy of renal transplant rejection and Wegener's granulomatosis, a study evaluates the safety of DSG in the therapy of lupus nephritis (LN). Patients with histologically proven active LN after prior treatment with at least one immunosuppressant were treated with 0.5 mg/kg normal body weight/day DSG, injected subcutaneously for 14 days, followed by a break of one week. These cycles were repeated to a maximum of 9 times. Doses of oral corticosteroids were gradually reduced to 7.5 mg/day or lower by cycle 4. Response was measured according to a predefined decision pattern. The dose of DSG was adjusted depending on the efficacy and side effects. Although the number of patients was small, results demonstrate that DSG appears to provide a tolerably safe treatment for LN. The improvement in proteinuria encourages larger controlled trials.
Arthritis Research & Therapy - Tue, 1 March 2011
http://arthritis-research.com/
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