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An 85-year-old man is admitted for evaluation of multiple papules, plaques, and subcutaneous nodules on his face, trunk, and extremities. The patient has itching. There is no history of trauma. He has an 8-year history of diabetes and Sjögren syndrome with eye and mouth involvement and has been treated with varied doses of oral methylprednisolone for 5 years.
Journal of the American Medical Association (Dermatology) - Tue, 31 January 2012
http://jama.ama-assn.org/
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People with psoriasis have nearly three times the risk of stroke and abnormal heart rhythm, according to scientists in Denmark.
BBC News (Dermatology) - Tue, 30 August 2011
http://news.bbc.co.uk
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Idiopathic aquagenic pruritus is a disabling disease which occurs after contact with water, involving intense itching without visible skin changes and without internal pathology nor drugs that can induce this symptom. The classical therapies are limited, including the addition of sodium bicarbonate to bath water, antihistaminics or phototherapy. In a study, published recently in The Journal of Allergy and Clinical Immunology, Nosbaum et al report an improvement of more than 90% in 5/6 patients 3-month treated by propranolol with minimal side effects. This therapeutic effect of propranolol, β-receptor antagonist of adrenaline, suggests an inappropriate activation of the sympathetic nervous system in the occurrence of idiopathic aquagenic pruritus.
American Academy of Allergy, Asthma and Immunology (Dermatology) - Tue, 7 June 2011
http://www.aaaai.org
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A team of German researchers has developed a new type of microscope that could help us better understand skin conditions like melanoma. The team, from the Fraunhofer Institute for Applied Optics and Precision Engineering (IOF) in Jena, Germany, ascertain that the new device can produce high-resolution images of skin areas of any size, unlike conventional microscopes that are restricted to producing images of one small area at a time.
Cordis - Community Research and Development Information Service (Dermatology) - Mon, 30 May 2011
http://cordis.europa.eu
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Patients with severe atopic eczema may require prolonged treatment with large amounts of highly potent topical corticosteroids and/or systemic treatment. In an upcoming issue of The Journal of Allergy and Clinical Immunology, Schram et al show results of the first head-to-head comparison of azathioprine versus methotrexate for the treatment of patients with severe atopic eczema. The authors conclude that both methotrexate and azathioprine are effective and safe short-term treatment options for adult patients with severe atopic eczema. The results from this study justify treatment with these drugs when routine treatment is insufficient. Long-term follow-up of these patients is necessary to gather additional information.
American Academy of Allergy, Asthma and Immunology (Dermatology) - Tue, 3 May 2011
http://www.aaaai.org
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Images of a hyperpigmented rash that involved the scrotum and both inguinal creases, that exhibited coral-red fluorescence under examination with ultraviolet A light from a Wood's lamp.
New England Journal of Medicine (Dermatology) - Mon, 4 April 2011
http://www.nejm.org
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Atopic dermatitis (AD) is a chronic inflammatory skin disorder that has been increasing in prevalence throughout the world over the past 30 years. At the same time, the prevalence of obesity has increased by more than double in children and adolescents over the past 30 years. There is increasing evidence that obesity can have numerous effects on the immune system. However, it was unknown how obesity affects atopic dermatitis. In a recent study published in The Journal of Allergy and Clinical Immunology at www.jacionline.org, Silverberg et al investigated the predisposing effect that obesity in childhood might have toward the development of AD. The authors studied the cases of 414 children and adolescents with AD and 828 healthy kids of similar ages and analyzed information about their weight. The results found that obesity in children predisposes toward developing AD and increases the severity of AD and the frequency of visits to the doctor for AD. Obesity predisposed toward AD when it occurred up to age 5, and was prolonged for more than 2.5 years. These findings suggest that weight loss in obese children may protect against or improve atopic dermatitis. Increased obesity in children may be a contributing factor in the rising prevalence of AD over the past few decades.
American Academy of Allergy, Asthma and Immunology (Dermatology) - Mon, 21 March 2011
http://www.aaaai.org
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A clinical image of a 29-year-old woman with angiofibromas, periungual fibromas, and a shagreen patch. All these are characteristic of tuberous sclerosis, an autosomal dominant disorder in which mutations in tumor suppressor gene TSC1 or TSC2 result in the formation of benign hamartomas throughout the body.
New England Journal of Medicine (Dermatology) - Mon, 21 March 2011
http://www.nejm.org
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This article summarises the most recent recommendations from the Scottish Intercollegiate Guidelines Network (SIGN) on the diagnosis and management of psoriasis and psoriatic arthritis in adults.
British Medical Journal (Dermatology) - Tue, 2 November 2010
http://www.bmjjournals.com
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Cream often prescribed to relieve the symptoms of eczema may be making the condition worse, researchers claim.
BBC News (Dermatology) - Mon, 18 October 2010
http://news.bbc.co.uk