Dermatology

Idiopathic aquagenic pruritus: efficacy of treatment with propranolol

Idiopathic aquagenic pruritus is a disabling disease which occurs after contact with water, involving intense itching without visible skin changes and without internal pathology nor drugs that can induce this symptom. The classical therapies are limited, including the addition of sodium bicarbonate to bath water, antihistaminics or phototherapy. In a study, published recently in The Journal of Allergy and Clinical Immunology, Nosbaum et al report an improvement of more than 90% in 5/6 patients 3-month treated by propranolol with minimal side effects. This therapeutic effect of propranolol, β-receptor antagonist of adrenaline, suggests an inappropriate activation of the sympathetic nervous system in the occurrence of idiopathic aquagenic pruritus.
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American Academy of Allergy, Asthma and Immunology