Dermatology

Facial Angiofibromas Associated with Tuberous Sclerosis

A clinical image of a 29-year-old woman with angiofibromas, periungual fibromas, and a shagreen patch. All these are characteristic of tuberous sclerosis, an autosomal dominant disorder in which mutations in tumor suppressor gene TSC1 or TSC2 result in the formation of benign hamartomas throughout the body.
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 http://www.nejm.org/doi/full/10.1056/NEJMicm1005598...

New England Journal of Medicine