Pharmacology

Tiotropium in Non-Controlled Asthma

When the administration of inhaled corticosteroids is not sufficient to control asthma symptoms, guidelines suggest the increase in cortisone dose or the adding of a long-acting beta-agonist, while anticholinergic drugs are first-choice drugs in patients with COPD. So, researchers have wondered whether these last products can obtain some benefits also in asthma: with a double-blinded, randomized trial, sponsored by NIH, with a crossover, 210 adults with asthma non-controlled by the usual therapy, treated with inhaled beclometasone (80 μg twice a day), have been treated in sequence with the adding of salmeterol, then with the adding of an anticholinergic (tiotropium) or with a double cortisone dose.
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