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What Is Important and to Whom?
The association between procedural volume and short-term mortality has been repeatedly demonstrated for coronary artery bypass graft (CABG) surgery.1-3 By virtue of this association it has been proposed that procedural volume, which can be easily measured, be used as a surrogate for quality, which is difficult to define and measure.
Archives of Internal Medicine - Tue, 31 August 2010
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Vitamin D has been known for many years to play a critical role in skeletal health, such that very low levels of this hormone (<20 nmol/L) can cause osteomalacia, a disorder of impaired bone mineralization.
Archives of Internal Medicine - Wed, 14 July 2010
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An Uncertain Association or a Credible Risk That Meaningfully Alters the Benefit-Risk Balance
Archives of Internal Medicine - Wed, 30 June 2010
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Promoting evidence-based medicine by encouraging adherence to evidence-based guidelines can substantially improve clinical care.
Archives of Internal Medicine - Wed, 30 June 2010
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Still Much We Don't Know
In this issue of the Archives, Ray et al and de Lorgeril et al reignite the long-simmering controversy concerning the use of lipid-lowering therapy for the primary prevention of cardiovascular and cerebrovascular events. Each article provides a different and valuable perspective.
Archives of Internal Medicine - Wed, 30 June 2010
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Chronic kidney disease (CKD) increases the risk of progression to end-stage renal disease (ESRD) and is associated with greater risk of death and of cardiovascular outcomes. Because the incidence of atherosclerotic cardiovascular disease is so much higher in patients with CKD than in the general population, the National Kidney Foundation (NKF) Task Force on Cardiovascular Disease concluded that patients with CKD should be considered to be in the highest risk category (ie, a coronary heart disease risk equivalent) for risk factor management, and the American Heart Association now recommends that all patients with cardiovascular disease should be screened for CKD.
Archives of Internal Medicine - Wed, 16 June 2010
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β-Blockers are highly efficacious in the treatment of congestive heart failure and ischemic coronary syndromes and can reduce the total mortality of patients with these disorders by 30% to 40%.
Archives of Internal Medicine - Mon, 31 May 2010
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Emergency research poses a fundamental ethical dilemma: prohibit valuable research because informed consent is not possible or enroll individuals in clinical trials without informed consent.
Archives of Internal Medicine - Mon, 3 May 2010
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Depression has long been recognized as a risk factor for developing cardiovascular disease in healthy individuals, for recurrent events in patients with established cardiovascular disease, and for adverse outcomes after coronary bypass surgery.
Archives of Internal Medicine - Mon, 19 April 2010
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The need is urgent to provide older persons with individualized information about the benefits and harms of different diagnostic and treatment strategies.
Archives of Internal Medicine - Mon, 29 March 2010
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