Neurology 

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  • Clinical image: Giant Basilar-Artery Aneurysm

    Computed tomography of the head revealed a circumferential midbrain lesion with mass effect and hydrocephalus. Magnetic resonance imaging (MRI) and magnetic resonance angiography revealed an aneurysm (3.5 cm by 4 cm) at the bifurcation of the basilar artery, with compression of the midbrain and probably the mamillary body; these findings were confirmed by cerebral angiography.

    New England Journal of Medicine (Neurology) - Tue, 13 November 2012
    http://www.nejm.org

  • Using The Eye As A ‘Window Into The Brain’

    An inexpensive, five-minute eye scan can accurately assess the amount of brain damage in people with the debilitating autoimmune disorder multiple sclerosis (MS), and offer clues about how quickly the disease is progressing, according to results of two Johns Hopkins studies.

    Johns Hopkins Hospital (Neurology) - Tue, 23 October 2012
    http://www.hopkinshospital.org

  • Personalized medicine in multiple sclerosis: hope or reality?

    Personalized treatment is highly desirable in Multiple Sclerosis (MS) because it is an immensely heterogeneous disease. This heterogeneity is seen in both the disease course and the treatment responses. Currently, a combination of clinical features and imaging parameters in MRI is used to classify active/non-active patients and treatment responders/non-responders. A review summarizes latest knowledge on this.

    BioMed Central (Neurology) - Mon, 8 October 2012
    http://www.biomedcentral.com

  • Can recordings help with dementia?

    Discovering the best way to help those with dementia deal with their condition is still in its early stages, but some research suggests that reminiscing about times-gone-by could make a difference.

    BBC News (Neurology) - Tue, 3 July 2012
    http://news.bbc.co.uk

  • Smaller forms of amyloid a possible target for Alzheimer's

    In a new study published in the scientific journal Neurology, scientists at Karolinska Institutet show that smaller forms of amyloid known as oligomers may be significant in the development of Alzheimer's disease - and are therefore a possible target for future drugs. These new findings add another piece to the puzzle of the complex dementia disease that affects so many people.

    Karolinska Institutet (Neurology) - Tue, 19 June 2012
    http://ki.se/ki/jsp/polopoly.jsp?d=130&l=en

  • Dabigatran in the Prevention of Stroke and TIA

    In the RE-LY study, on patients affected by atrial fibrillation and with a stroke risk, the administration of dabigatran (an oral inhibitor of thrombin) has reduced the risk of stroke and has presented a bleeding risk superimposable to the ones of warfarin.

    MedNews (Neurology) - Mon, 14 May 2012
    http://mn.medsurfnews.com/

  • Survival in Patients with Advanced Dementia

    One of the questions with no answer is the one relative to survival in patients with an advanced stage of dementia, and the answer to this question often influences the decisions of possible hospitalizations in palliative care structures. With a prospective study, the prevision of death among 606 patients hospitalized in a protected structure in Massachusetts have been examined, according to two parameters: the ADEPT (Advanced Dementia Prognostic Tool) score, an evaluation scale including 12 factors, among which age, presence of trophic ulcers, incontinence, recent weight loss, where the scale ranges from 1 to 32.5 points and where the highest score indicates a lower survival.

    MedNews (Neurology) - Wed, 2 May 2012
    http://mn.medsurfnews.com/

  • Higher maternal age increases risk of autism

    Researchers have analyzed past studies to investigate possible associations between maternal age and autism spectrum disorder. While much research has been done to identify potential genetic causes of autism, the current analysis suggests that non-heritable and environmental factors may also play a role in children's risk for autism.

    Karolinska Institutet (Neurology) - Wed, 2 May 2012
    http://ki.se/ki/jsp/polopoly.jsp?d=130&l=en

  • Nano-Devices that Cross Blood-Brain Barrier Open Door to Treatment of Cerebral Palsy, Other Neurologic Disorders

    A team of scientists from Johns Hopkins and elsewhere have developed nano-devices that successfully cross the brain-blood barrier and deliver a drug that tames brain-damaging inflammation in rabbits with cerebral palsy. For the study, researchers used tiny, manmade molecules laced with N-acetyl-L-cysteine (NAC), an anti-inflammatory drug used as antidote in acetaminophen poisoning. The researchers precision-targeted brain cells gone awry to halt brain injury. In doing so they improved the animals’ neurologic function and motor skills.

    Johns Hopkins Hospital (Neurology) - Tue, 24 April 2012
    http://www.hopkinshospital.org

  • Tricyclics in Migraine

    In patients suffering from migraine and tension-type headache, in general tricyclic agents are prescribed, even if antidepressants market has been occupied almost entirely by more recent drugs, like SSRIs. In order to compare their efficacy, a meta-analysis has been performed on 37 randomized studies involving about 3200 people (averagely 40 years of age; 73% females) and lasted averagely 10 weeks; the studies had been performed to compare the efficacy of tricyclic agents with placebo, with SSRIs and with beta-blockers in the treatment of migraine and of tension-type headache.

    MedNews (Neurology) - Mon, 23 April 2012
    http://mn.medsurfnews.com/

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