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  • Smaller forms of amyloid a possible target for Alzheimer's

    In a new study published in the scientific journal Neurology, scientists at Karolinska Institutet show that smaller forms of amyloid known as oligomers may be significant in the development of Alzheimer's disease - and are therefore a possible target for future drugs. These new findings add another piece to the puzzle of the complex dementia disease that affects so many people.

    Karolinska Institutet (Neurology) - Tue, 19 June 2012

  • Dabigatran in the Prevention of Stroke and TIA

    In the RE-LY study, on patients affected by atrial fibrillation and with a stroke risk, the administration of dabigatran (an oral inhibitor of thrombin) has reduced the risk of stroke and has presented a bleeding risk superimposable to the ones of warfarin.

    MedNews (Neurology) - Mon, 14 May 2012

  • Survival in Patients with Advanced Dementia

    One of the questions with no answer is the one relative to survival in patients with an advanced stage of dementia, and the answer to this question often influences the decisions of possible hospitalizations in palliative care structures. With a prospective study, the prevision of death among 606 patients hospitalized in a protected structure in Massachusetts have been examined, according to two parameters: the ADEPT (Advanced Dementia Prognostic Tool) score, an evaluation scale including 12 factors, among which age, presence of trophic ulcers, incontinence, recent weight loss, where the scale ranges from 1 to 32.5 points and where the highest score indicates a lower survival.

    MedNews (Neurology) - Wed, 2 May 2012

  • Higher maternal age increases risk of autism

    Researchers have analyzed past studies to investigate possible associations between maternal age and autism spectrum disorder. While much research has been done to identify potential genetic causes of autism, the current analysis suggests that non-heritable and environmental factors may also play a role in children's risk for autism.

    Karolinska Institutet (Neurology) - Wed, 2 May 2012

  • Nano-Devices that Cross Blood-Brain Barrier Open Door to Treatment of Cerebral Palsy, Other Neurologic Disorders

    A team of scientists from Johns Hopkins and elsewhere have developed nano-devices that successfully cross the brain-blood barrier and deliver a drug that tames brain-damaging inflammation in rabbits with cerebral palsy. For the study, researchers used tiny, manmade molecules laced with N-acetyl-L-cysteine (NAC), an anti-inflammatory drug used as antidote in acetaminophen poisoning. The researchers precision-targeted brain cells gone awry to halt brain injury. In doing so they improved the animals’ neurologic function and motor skills.

    Johns Hopkins Hospital (Neurology) - Tue, 24 April 2012

  • Tricyclics in Migraine

    In patients suffering from migraine and tension-type headache, in general tricyclic agents are prescribed, even if antidepressants market has been occupied almost entirely by more recent drugs, like SSRIs. In order to compare their efficacy, a meta-analysis has been performed on 37 randomized studies involving about 3200 people (averagely 40 years of age; 73% females) and lasted averagely 10 weeks; the studies had been performed to compare the efficacy of tricyclic agents with placebo, with SSRIs and with beta-blockers in the treatment of migraine and of tension-type headache.

    MedNews (Neurology) - Mon, 23 April 2012

  • Symptoms That Mimic Epilepsy LInked to Stress, Poor Coping Skills

    Based on their clinical experience and observations, a team of Johns Hopkins physicians and psychologists concluded that more than one-third of the patients admitted to The Johns Hopkins Hospital’s inpatient epilepsy monitoring unit for treatment of intractable seizures have been discovered to have stress-triggered symptoms rather than a true seizure disorder.

    Johns Hopkins Hospital (Neurology) - Tue, 17 April 2012

  • Spinal injections may not aid lower back pain

    A new study suggests that injections of steroids or arthritis drugs in the spine may not provide much extra relief for people with chronic back and leg pain due to nerve damage.

    Reuters (Neurology) - Tue, 17 April 2012

  • Vitamin B and Cognitive Processes

    According to many epidemiological studies, we know that the increase in plasmatic homocysteine is associated with a decrease in cognitive functions, so researchers consequently wondered whether vitamin B supplementation, capable to decrease the levels of homocysteine, can avoid or delay cognitive decrease.

    MedNews (Neurology) - Tue, 10 April 2012

  • Uncovering drugs that boost cognitive function

    Researchers have discovered that there are a number of drugs that give cognitive function a boost. These drugs could help fuel our understanding of cognitive disorders, including Alzheimer's disease.

    Health-EU (Neurology) - Tue, 20 March 2012

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