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Minocycline is a clinically available antibiotic and anti-inflammatory drug that also demonstrates neuroprotective properties in a variety of experimental models of neurological diseases. There have thus far been more than 300 publications on minocycline neuroprotection including a growing number of human studies. Our objective is to critically review the biological basis and translational potential of this action of minocycline on the nervous system.
Archives of Neurology (Neurology) - Tue, 31 August 2010
http://archneur.ama-assn.org/
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Mental health professionals say that more children are receiving diagnoses for bipolar disorder, and at younger ages. This is a serious brain disorder that may include episodes of mania and depression, intense excitement and even suicidal behavior.
CNN.com (Neurology) - Tue, 31 August 2010
http://www.cnn.com
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Last week, semagacestat added itself to the phase 3 scrapheap of other disease-modifying hopefuls for Alzheimer's disease. This drug is a γ-secretase inhibitor of the final step in amyloid-β protein synthesis, aggregates of which form plaques, the hallmark of the disease.
The Lancet (Neurology) - Tue, 31 August 2010
http://www.thelancet.com
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Professor Carol Brayne explains finding that suggest early education helps people compensate against dementia in later life
BBC News (Neurology) - Mon, 26 July 2010
http://news.bbc.co.uk
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In the United Kingdom, the actual number of people with Huntington's does not support previous population estimates; more research is needed.
Medscape (Neurology) - Mon, 26 July 2010
http://www.medscape.com
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Now that there are tests in the works for early detection of brain injury due to Alzheimer's, children of parents with Alzheimer's ponder whether they would want to know their risk.
CNN.com (Neurology) - Thu, 22 July 2010
http://www.cnn.com
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obstructive sleep apnea in patients with atrial fibrillation who could benefit from treatment of the sleep disorder.
Medscape (Neurology) - Thu, 22 July 2010
http://www.medscape.com
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The onset of a cervical radiculopathy is characteristic: pain originated in the neck and irradiated to the upper limb, with a sensitive and motor deficit corresponding to the spinal root at issue. In general, the problem spontaneously clears up within 6 weeks, but in this period, pain intensity can become severe and invalidating, so the proposed treatments are various.
MedNews (Neurology) - Wed, 14 July 2010
http://mn.medsurfnews.com/
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Two years ago, Newmark and Newmark hypothesized that insufficient vitamin D could play a role in the pathogenesis of Parkinson disease (PD). The study by Knekt et al in this issue of the Archives is the first longitudinal analysis of vitamin D status as a risk of incident PD and examines a cohort of more than 3000 participants from the Mini-Finland Health Survey.
Archives of Neurology (Neurology) - Wed, 14 July 2010
http://archneur.ama-assn.org/
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There is convincing evidence that the Parkinson disease neurodegenerative process begins many years before the onset of motor manifestations. Initial estimates based on nigral neuropathological findings or striatal dopamine imaging suggested a 5- to 6-year preclinical period. However, more recent evidence of Lewy body pathology in other neuronal populations preceding nigral involvement suggests that the preclinical phase may be much longer. Epidemiologic studies of nonmotor manifestations, such as constipation, anxiety disorders, rapid eye movement sleep behavior disorder (RBD), and anemia, suggest that the preclinical period extends at least 20 years before the motor manifestations. Olfactory impairment and depression may also precede the onset of motor manifestations; however, the lag time may be shorter. Recognition of a nonmotor preclinical phase spanning 20 or more years should guide the search for predictive biomarkers and the identification of risk or protective factors for Parkinson disease.
Archives of Neurology (Neurology) - Wed, 14 July 2010
http://archneur.ama-assn.org/