Diabetology

Weekly Exenatide

In type 2 diabetes, you can use incretin-mimetic drugs to stimulate insulin secretion and mitigate glucagone release, slowing gastric emptying at the same time. Among these ones, exenatide (an agonist of glucagone-like peptide-1 ( GLP-1) receptors) needs one-two daily administrations, so a long-acting formulation is being studied, with a weekly administration. Sitagliptin (an inhibitor of dipeptidyl-peptidase-4) is based on a similar mechanism of action, slowing the degradation of endogenous GLP-1. This kind of drugs can represent therapeutical alternatives to sulfonylurea or to thiazolidinediones, when metformin alone is not capable to control diabetes.
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