Infectious Diseases

CD4+ Count-Guided Interruption of Antiretroviral Treatment

Long-term antiretroviral therapy for the treatment of human immunodeficiency virus infection is associated with a substantial rate of complications. Structured interruption of antiretroviral therapy, in the setting of a preserved CD4+ count, has been considered in order to minimize these side effects. In this randomized study of 5472 patients, CD4+ count-guided intermittent use of antiretroviral drugs was found to be associated with increased rates of opportunistic disease, death from any cause, and severe adverse events, as compared with the continuous use of antiretroviral therapy.
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 http://content.nejm.org/cgi/content/short/355/22/2283?rss=1&...

New England Journal of Medicine