Orthopaedics

Thrombotic Prophylaxis in Orthopedic Surgery

In patients undergoing orthopedic surgery, a long-acting anti-thrombotic prophylaxis is usually performed, but is this practice really useful and necessary? Through a multinational trial, sponsored by pharmaceutical industry, the efficacy of a long-term prophylaxis in acute patients has been assessed: everybody has been treated with enoxaparin for 10 days, then all have been randomized to receive further injections of heparin or placebo for 28 further days. Controls have been made when 75% of enrolment was reached (3685 patients) and there have been no differences between enoxaparin and placebo as to thromboembolic events; there has been, instead, a greater tendency to bleeding episodes in the group treated with heparin (0.6% vs. 0.29%).
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 http://mn.medsurfnews.com/contents/en/6195/display/thromboti...

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