Orthopaedics 

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  • Bisphosphonate-Associated Osteonecrosis of the Jaw

    A 54-year-old man with a 3-year history of IgG myeloma, complicated by hypercalcemia, who was being treated with dexamethasone, lenalidomide, filgrastim, darbepoetin alfa, and pamidronate, presented with a 1-month history of severe bilateral jaw pain.

    New England Journal of Medicine (Orthopaedics) - Thu, 30 November 2006
    http://www.nejm.org

  • Osteonecrosis of the Jaw — Do Bisphosphonates Pose a Risk?

    Nitrogen-containing bisphosphonates are used widely for the management of metastatic cancer in bone (intravenous zoledronic acid or pamidronate), for the prevention and treatment of osteoporosis (oral alendronate, risedronate, and ibandronate and intravenous ibandronate), for the treatment of Paget's disease of bone (intravenous pamidronate and oral alendronate and risedronate), and for the short-term management of acute hypercalcemia (intravenous zoledronic acid and pamidronate).

    New England Journal of Medicine (Orthopaedics) - Thu, 30 November 2006
    http://www.nejm.org

  • Signaling for cartilage

    Skeletal progenitor cells differentiate into cartilage cells when one master gene actually suppresses the action of another, said Baylor College of Medicine researchers in a report that appears online in the journal Proceedings of the National Academy of Sciences.

    Baylor College of Medicine (Orthopaedics) - Wed, 29 November 2006
    http://www.bcm.edu

  • Inhaled Corticosteroid Use May Be an Independent Risk Factor for Fracture

    A study confirms that use of inhaled corticosteroids is associated with increased risk for fractures in patients with asthma or COPD.

    Medscape (Orthopaedics) - Tue, 17 October 2006
    http://www.medscape.com

  • Bone Density Evaluation in Teens Prevents Future Osteoporosis

    A review published in the October issue of the Archives of Pediatrics & Adolescent Medicine describes the most effective methods to evaluate bone density in teens to prevent future osteoporosis.

    Medscape (Orthopaedics) - Fri, 13 October 2006
    http://www.medscape.com

  • Safety and efficacy of routine postoperative ibuprofen for pain and disability related to ectopic bone formation after hip replacement surgery (HIPAID): randomised controlled trial

    Chronic symptomatic osteoarthritis of the hip is common in those aged over-50 and total hip replacement is a well established and highly effective treatment. Objectives of this study is to determine the benefits and risks of a non-steroidal anti-inflammatory drug (NSAID) as prophylaxis for ectopic bone formation in patients undergoing total hip replacement (or revision) surgery.

    British Medical Journal (Orthopaedics) - Wed, 12 July 2006
    http://www.bmjjournals.com
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