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Neurology
For over a decade, the drug called tPA has proven its worth as the most effective emergency treatment for stroke. Its promise is blemished by the fact that tPAs brain-saving power fades fast after the third hour of a stroke, and then instead increases the risk of dangerous bleeding in the brain. But a recent study by Swedish and American scientists now show that these problems might be overcome, if a stroke patient first takes a drug currently used to treat leukemia.
Karolinska Institutet - Fri, 27 June 2008
http://ki.se/ki/jsp/polopoly.jsp?d=130&l=en
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Dermatology
The National Institute for Health and Clinical Excellence (NICE) has published guidance on the use of adalimumab for the treatment of psoriasis in adults.
National Institute for Health and Clinical Excellence - Fri, 27 June 2008
http://www.nice.org.uk
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Dietetics and Nutrition
The National Institute for Health and Clinical Excellence (NICE) has today (25 June) published final guidance on the use of rimonabant for the treatment of overweight and obese patients.
National Institute for Health and Clinical Excellence - Fri, 27 June 2008
http://www.nice.org.uk
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Allergology
According to research to be published in an upcoming issue of the Journal of Allergy and Clinical Immunology, a second dose of epinephrine - the drug of choice for treating severe allergic reactions - was needed in nearly 1-of-5 cases of food-induced anaphylaxis in children.
American Academy of Allergy, Asthma and Immunology - Fri, 27 June 2008
http://www.aaaai.org
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Cardiology
Hippisley-Cox and colleagues develop and validate the second version of the QRISK cardiovascular disease risk algorithm (QRISK2), an attempt to more accurately estimate cardiovascular risk in patients from different ethnic groups in England and Wales.
British Medical Journal - Fri, 27 June 2008
http://www.bmjjournals.com
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Neurology
The authors explore whether migraine affects pregnancy, how pregnancy alters migraine, and how to treat and prevent migraine in pregnancy.
British Medical Journal - Fri, 27 June 2008
http://www.bmjjournals.com
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Genetics e Rare diseases
Progressive enlargement of the aortic root, leading to dissection, is the main cause of premature death in patients with Marfan's syndrome. Recent data from mouse models of Marfan's syndrome suggest that aortic-root enlargement is caused by excessive signaling by transforming growth factor β (TGF-β) that can be mitigated by treatment with TGF-β antagonists, including angiotensin II–receptor blockers (ARBs).
New England Journal of Medicine - Fri, 27 June 2008
http://www.nejm.org
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Oncology
This article reviews the genetic susceptibility to breast cancer, with emphasis on genomewide association studies that have uncovered six single-nucleotide polymorphisms with a strong statistical association with breast cancer.
New England Journal of Medicine - Fri, 27 June 2008
http://www.nejm.org
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Cardiology
Treating hypertension decreases mortality and disability from cardiovascular disease, but most hypertension remains inadequately controlled.
Journal of the American Medical Association - Fri, 27 June 2008
http://jama.ama-assn.org/
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Cardiology
If viewed through the lens of its most common complaints—loud snoring, disrupted sleep, and excessive daytime sleepiness—obstructive sleep apnea (OSA) may seem to be more of an annoyance rather than a condition with potentially serious health effects.
Journal of the American Medical Association - Fri, 27 June 2008
http://jama.ama-assn.org/