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Pharmacology
The greatest public health benefit of advances in understanding the human genome may be realized for common chronic diseases such as cardiovascular disease, diabetes mellitus, and cancer. Attempts to integrate such knowledge into clinical practice are still in the early stages, and as a result, many questions surround the current state of this translation.
Journal of the American Medical Association - Wed, 19 March 2008
http://jama.ama-assn.org/
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Angiology
Objective of the study is to identify single-nucleotide polymorphisms (SNPs) associated with DVT.
Journal of the American Medical Association - Wed, 19 March 2008
http://jama.ama-assn.org/
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Oncology
Classic genetics alone cannot explain the diversity of phenotypes within a population. Nor does classic genetics explain how, despite their identical DNA sequences, monozygotic twins or cloned animals can have different phenotypes and different susceptibilities to a disease. The concept of epigenetics offers a partial explanation of these phenomena.
New England Journal of Medicine - Wed, 19 March 2008
http://www.nejm.org
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Oncology
Despite optimal and early surgical treatment of non–small-cell lung cancer (NSCLC), many patients die of recurrent NSCLC. Scientists investigated the association between gene methylation and recurrence of the tumor.
New England Journal of Medicine - Wed, 19 March 2008
http://www.nejm.org
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Cardiology
The National Institute for Health and Clinical Excellence (NICE) has today issued a clinical guideline on antibiotic prophylaxis against infective endocarditis (IE).
National Institute for Health and Clinical Excellence - Wed, 19 March 2008
http://www.nice.org.uk
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Angiology
One way of combating atherosclerosis is to reduce levels of "bad cholesterol" in the blood. Scientists at the Swedish medical university Karolinska Institutet have now identified the genes that bring about this beneficial effect.
Karolinska Institutet - Wed, 19 March 2008
http://ki.se/ki/jsp/polopoly.jsp?d=130&l=en
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Rheumatology
A gluten-free vegan diet may improve the health of patients with rheumatoid arthritis, according to new research from Karolinska Institutet. The diet has a beneficial effect on several risk factors for cardiovascular disease.
Karolinska Institutet - Wed, 19 March 2008
http://ki.se/ki/jsp/polopoly.jsp?d=130&l=en
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Andrology
A team of NIGMS-supported scientists has identified an X chromosome gene involved in meiosis that when disrupted renders male mice sterile and female mice less fecund.
National Institute of General Medical Sciences - Wed, 19 March 2008
http://www.nigms.nih.gov/
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Cardiology
A review describes the benefits, guidelines for use, and protective effects of omega-3 fatty acid intake on cardiovascular health.
Medscape - Wed, 19 March 2008
http://www.medscape.com
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Infectious Diseases
Organs transplanted from a donor with disseminated tuberculosis resulted in disease transmission to 2 of 3 organ recipients, according to a new study.
Medscape - Wed, 19 March 2008
http://www.medscape.com