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Diabetology
A study has validated the Infectious Diseases Society of America's classification system for foot infections in patients with diabetes, which is designed to provide better outcomes.
Medscape - Wed, 7 February 2007
http://www.medscape.com
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Pharmacology
One third of the drugs tested separately in children had different effects than in adults; some were more toxic, and others were completely ineffective.
Medscape - Wed, 7 February 2007
http://www.medscape.com
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Obstetrics and Gynecology
In a randomized controlled trial, women with polycystic ovary syndrome had better cardiopulmonary functional capacity after a 3-month exercise training program.
Medscape - Wed, 7 February 2007
http://www.medscape.com
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Oncology
A 2-step approach to the treatment of squamous cell carcinoma using curettage of the lesion followed by 6 weeks of imiquimod 5% cream results in a 97% clearance rate, investigators reported here at the 65th annual meeting of the American Academy of Dermatology.
Medscape - Wed, 7 February 2007
http://www.medscape.com
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Oncology
A new review confirms a survival benefit from aromatase inhibitors in advanced breast cancer.
Medscape - Wed, 7 February 2007
http://www.medscape.com
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Pharmacology
FDA informed consumers and healthcare professionals of the potential hazards of using skin numbing products containing topical anesthetic drugs such as lidocaine, tetracaine, benzocaine, and prilocaine in a cream, ointment, or gel.
Food and Drug Administration - Wed, 7 February 2007
http://www.fda.gov
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Cardiology
Acute safety concerns have been raised recently regarding certain hemorrhage-sparing medications commonly used in cardiac surgery. However, no comprehensive data exist regarding their associations with long-term mortality.
Journal of the American Medical Association - Tue, 6 February 2007
http://jama.ama-assn.org/
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Pharmacology
In 1997, Congress authorized the US Food and Drug Administration (FDA) to grant 6-month extensions of marketing rights through the Pediatric Exclusivity Program if industry sponsors complete FDA-requested pediatric trials.
Journal of the American Medical Association - Tue, 6 February 2007
http://jama.ama-assn.org/
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Angiology
Although the roles of clotting proteins and enzymes that activate or inhibit fibrin production and lysis are well characterized, the underlying contribution of genetic variation in these constituents to risk of venous thrombosis (VT) has not been fully investigated.
Journal of the American Medical Association - Tue, 6 February 2007
http://jama.ama-assn.org/
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Cardiology
Statins reduce low-density lipoprotein cholesterol (LDL-C) levels and slow progression of coronary atherosclerosis. However, no data exist describing the relationship between statin-induced changes in high-density lipoprotein cholesterol (HDL-C) and disease progression.
Journal of the American Medical Association - Tue, 6 February 2007
http://jama.ama-assn.org/