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Nephrology
In light of the recent FDA warning about an association between gadolinium-based contrast agents and nephrogenic systemic fibrosis in patients with severe renal failure, a team from Yale University says dialysis should be aggressively used as soon as possible after magnetic resonance investigations in such patients.
Medscape - Tue, 16 January 2007
http://www.medscape.com
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Neurology
Investigators have shown a higher intake of folate is associated with a decreased risk for Alzheimer's disease in a cohort of subjects who had a high prevalence of vascular risk factors.
Medscape - Tue, 16 January 2007
http://www.medscape.com
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Oncology
Sunitinib is one of several new antiangiogenic agents undergoing tests of efficacy in the treatment of various types of cancer. Renal-cell carcinoma of the clear-cell type is particularly important in this regard because of the evidence that mutations in the VHL gene result in stimulation of cellular receptors that promote angiogenesis and tumor growth. This trial found promising results with sunitinib in the treatment of metastatic renal-cell cancer.
New England Journal of Medicine - Tue, 16 January 2007
http://www.nejm.org
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Infectious Diseases
This study analyzed the response to nevirapine-based antiretroviral treatment among 218 HIV-infected women in Botswana who had previously received either a single dose of nevirapine or placebo at the time of labor.
New England Journal of Medicine - Tue, 16 January 2007
http://www.nejm.org
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Angiology
Homozygous familial hypercholesterolemia is a serious disorder resulting in early-onset vascular disease. This preliminary study explored a new therapy, an inhibitor of microsomal triglyceride transfer protein, which was very effective in lowering low-density lipoprotein cholesterol levels.
New England Journal of Medicine - Tue, 16 January 2007
http://www.nejm.org
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Cardiology
Recent studies of drug-eluting intracoronary stents suggest that current antiplatelet regimens may not be sufficient to prevent late stent thrombosis. Objective of the study is to assess the association between clopidogrel use and long-term clinical outcomes of patients receiving drug-eluting stents (DES) and bare-metal stents (BMS) for treatment of coronary artery disease.
Journal of the American Medical Association - Tue, 16 January 2007
http://jama.ama-assn.org/
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Cardiology
Identification of individuals at high risk for cardiovascular events is important for the optimal use of primary and secondary prevention measures. Objective is to determine whether plasma levels of amino terminal fragment of the prohormone brain-type natriuretic peptide (NT-proBNP) predict cardiovascular events or death independent of other available prognostic tests.
Journal of the American Medical Association - Tue, 16 January 2007
http://jama.ama-assn.org/
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Cardiology
The extent to which drug adherence may affect survival remains unclear, in part because mortality differences may be attributable to "healthy adherer" behavioral attributes more so than to pharmacological benefits. Objective is to explore the relationship between drug adherence and mortality in survivors of acute myocardial infarction (AMI).
Journal of the American Medical Association - Tue, 16 January 2007
http://jama.ama-assn.org/
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Oncology
Carcinogens associated with head and neck squamous cell carcinoma (SCC) genesis should inflict genomic alterations not only on the epithelium but also the mesenchyme of the aerodigestive tract. Therefore, the apparently nonmalignant stroma surrounding the tumor epithelium can acquire genomic alterations and contribute to cancer initiation and progression.
Journal of the American Medical Association - Tue, 16 January 2007
http://jama.ama-assn.org/
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Dermatology
Objective of the study is to evaluate the cost-effectiveness of various melanoma screening strategies proposed in the United States.
Archives of Dermatology - Tue, 16 January 2007
http://archderm.ama-assn.org/