Oncology

Steps solidifying a role for SEPT9 in breast cancer suggest that greater strides are needed

Human septins are a conserved family of GTPase proteins, encoded at thirteen loci scattered throughout the human genome. Of these, SEPT9 has been most widely implicated in diverse cancers of epithelial origin, including breast cancer, as well as leukemia. In this issue, Connolly et al. present compelling data that further supports a role for involvement of SEPT9 isoforms early in mammary tumorigenesis as well as intriguing evidence that suggests that different cellular localization patterns of SEPT9 isoforms may be a contributing factor in oncogenesis.
Read more

 http://breast-cancer-research.com/content/14/1/101...

Breast Cancer Research