Pharmacology

Clopidogrel and Protonic Pump Inhibitors

According to recent trials, we know that the efficacy of clopidogrel is decreased by the contemporary assumption of protonic pump inhibitors (PPIs) because of the interference with the activity of cytochrome CYP2C19. In this retrospective trial, the risk of a new hospitalization for infarction or for coronary stent positioning has been assessed in 2066 patients (averagely 69 years of age) discharged after infarction or coronary revascularization. About half of the subjects had been treated with clopidogrel alone and the other half with a contemporary assumption of a PPI.
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 http://mn.medsurfnews.com/contents/en/6063/display/clopidogr...

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