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A study shows some morbidly obese people are missing a section of DNA.
Medscape (Endocrinology) - Fri, 5 February 2010
http://www.medscape.com
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Gout has been referred to in the past as “the king of diseases and the disease of kings”, as Pascal Richette and Thomas Bardin write in their Seminar in The Lancet today. However, the perception of the disease among the public and the way in which the condition is currently managed in the clinic has not befitted this grand reference. The public often consider gout—the most common inflammatory arthritis in men in developed countries—to be solely a self-inflicted ailment caused by excessive consumption of alcohol and rich food. Meanwhile, treatment for gout has not been optimum because many practitioners confuse the management of acute gout and hyperuricaemia. Furthermore, because gout is an ancient disease (it was first described by the Egyptians in 2640 BCE), it has not been a high priority for the pharmaceutical industry when compared with rheumatoid arthritis. Combined, these factors have meant that gout has been somewhat neglected.
The Lancet (Endocrinology) - Mon, 1 February 2010
http://www.thelancet.com
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Should Glucocorticoid-Induced Hyperglycemia Be Treated in Patients With Septic Shock?
Greet Van den Berghe, MD, PhD
JAMA. 2010;303(4):365-366.
Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.
Critical illness, in particular severe sepsis, induces insulin resistance and hyperglycemia. Corticosteroids are often used for reversal of fluid- and vasopressor-resistant septic shock. Such an adjuvant treatment aggravates illness-induced hyperglycemia, even in a low-dose steroid regimen. For glucocorticoid-induced hyperglycemia in noncritically ill patients, there is general agreement on treatment, because prolonged hyperglycemia causes cardiovascular and infectious complications. Whether patients in septic shock in the intensive care unit (ICU) with glucocorticoid-induced aggravation of "diabetes of injury" should be treated is controversial. This debate is embedded in the overall controversy about whether to treat critically ill patients with hyperglycemia with insulin, and if so, to what blood glucose level.
Journal of the American Medical Association (Endocrinology) - Mon, 1 February 2010
http://jama.ama-assn.org/
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Hormones likely play a role in the development of adult acne. Some adult women experience mild to moderate acne due to hormonal changes associated with pregnancy, menstruation, and stopping and starting birth control pills. But hormones generally are not the root cause of acne.
MayoClinic.com (Endocrinology) - Fri, 22 January 2010
http://www.mayoclinic.com
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The link between obesity and mortality from cardiovascular disease, diabetes and certain forms of cancer may be substantially underestimated, according to a new study from Karolinska Institutet. The study, which is published in the scientific journal BMJ, also suggests that some of the adverse consequences of being underweight may be overstated.
Karolinska Institutet (Endocrinology) - Thu, 7 January 2010
http://ki.se/ki/jsp/polopoly.jsp?d=130&l=en
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The term subclinical hypothyroidism (SCH) was coined by Bastenie et al in 1967, and the entity has remained a subject of a heated debate among clinicians ever since. There appears to be agreement on the basic definition of SCH as the finding of a thyrotropin (TSH) level above the upper limit of the reference range in the presence of normal reference range levels of serum free thyroxine (FT4) and free triiodothyronine (FT3). The controversy relates in part to just what is the normal reference range for TSH level, specifically the upper limit of the range beyond which a diagnosis of hypothyroidism would obtain.
Archives of Internal Medicine (Endocrinology) - Fri, 27 November 2009
http://archinte.ama-assn.org/
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In this issue of JAMA, Kuklina and colleagues report trends over the last decade in cholesterol levels and treatment. While the decreasing prevalence of "high" low-density lipoprotein cholesterol (LDL-C) levels and increasing use of lipid-lowering medications in appropriate individuals are encouraging, the most sobering message in this article is the disappointing rates of screening, awareness, and treatment. Among those with high LDL-C levels, one-third had not been screened, and one-fourth were unaware that their levels were high. About two-thirds of those who were high risk were not receiving medication, although the vast majority of these individuals would likely benefit from lipid-lowering therapy.
Journal of the American Medical Association (Endocrinology) - Tue, 24 November 2009
http://jama.ama-assn.org/
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The frequency of obesity has risen dramatically in recent years but only few safe and effective drugs are currently available. We assessed the effect of liraglutide on bodyweight and tolerability in obese individuals without type 2 diabetes.
The Lancet (Endocrinology) - Fri, 6 November 2009
http://www.thelancet.com
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The US Food and Drug Administration (FDA) is working to reduce drug-induced liver damage with an initiative targeting the use of acetaminophen—the most common cause of such adverse events. The agency also is promoting research on genetic factors that may contribute to drug-related liver problems.
Drug-induced liver failure is a growing concern for the FDA. Cases of acute liver failure reported to the agency's Adverse Events Reporting System (AERS) have increased from 89 in 1995 to 404 in 2005, and acetaminophen is the drug most commonly implicated in such reports.
Journal of the American Medical Association (Endocrinology) - Mon, 27 July 2009
http://jama.ama-assn.org/
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Gaucher's disease — Comprehensive overview covers symptoms, causes, treatment of this metabolic disorder.
MayoClinic.com (Endocrinology) - Mon, 13 July 2009
http://www.mayoclinic.com